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G:BOX Chemi XX6 targets Alzheimer’s
December 2015
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FREDERICK, Md.—Syngene has announced that scientists at Italy’s University of Brescia are using the G:BOX Chemi XX6 multi-application imager to analyze nitrated proteins. Specifically, researchers from the university’s department of Molecular and Translational Medicine (DMMT) are applying Syngene’s system to analyze nitrated proteins fluorescently stained with Cy2, Cy3 and Cy5 on 2D difference gel electrophoresis (DIGE) gels to gather accurate information on protein changes and potentially identify Alzheimer’s disease biomarkers.
 
“We have been sampling blood from healthy volunteers and Alzheimer’s disease patients for around 15 years, but the amount of nitrated proteins we’re looking for to indicate disease onset is very small, so we need to use a DIGE approach to find them. This means we have to have sensitive detection with an imager that can visualize nanogram amounts of protein,” said Dr. Daniela Uberti, assistant professor of pharmacology in the DMMT at the University of Brescia.
 
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