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ANAVEX 2-73 shows promise for rare seizure disorder
July 2016
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NEW YORK—In a preclinical study, Anavex Life Sciences Corp.'s ANAVEX 2-73 was found to significantly reduce the number of spasms in infant rats with infantile spasms (epileptic spasms). Dr. Libor Velisek and his lab at New York Medical College sponsored and performed the study. Following prenatal priming with betamethasone in infant rats, spasms were recorded for 90 minutes following postnatal trigger of spasms with NMDA injection. Treating the rats with ANAVEX 2-73 reduced the number of spasms by 55 percent compared to vehicle.
 
“Our team has tested many different compounds with strong rationale for potential effect in infantile spasms. However, ANAVEX 2-73 is by far the only highly effective compound we have worked with apart from the adrenocorticotropic hormone,” said Velisek. “I believe that a continuation of studies with ANAVEX 2-73 is fully justified.”

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