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Microarray analysis makes strong showing in miscarriage testing
August 2016
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IRVINE, Calif.—CombiMatrix Corp. has announced the publication of data from a retrospective study showing a high success rate and superior diagnostic power of chromosomal microarray analysis for recurrent pregnancy loss testing. The company analyzed more than 8,000 consecutive products of conception samples, with results obtained successfully for more than 90 percent of the cases, compared to success rates of 60 to 80 percent for samples evaluated with the standard approach of karyotyping.
 
“Our high success rate with evaluating challenging POC samples includes both fresh and formalin-fixed, paraffin-embedded samples, thus providing significant advantages and options to clinicians and providers. Further, the ability of single nucleotide polymorphism-based microarray analysis to identify aneuploidy, polyploidy, whole-genome homozygosity, segmental genomic imbalances and maternal cell contamination maximizes sensitivity and decreases the number of false-negative results,” commented study author Dr. Trilochan Sahoo, CombiMatrix’s vice president of clinical affairs and director of cytogenetics.

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