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NeuVax vaccination reduces tumor growth in mouse models
November 2016
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SAN RAMON, Calif.—Biopharmaceutical company Galena Biopharma Inc. recently shared preclinical data regarding its NeuVax program at the Progress in Vaccination Against Cancer Conference. NeuVax is a first-in-class, HER2-directed cancer immunotherapy currently being assessed for its ability to prevent breast cancer recurrence after standard-of-care treatment in the adjuvant setting. The study in question featured HLA-A2 transgenic mice that were immunized with NeuVax (E75) mixed with recombinant mouse GM-CSF. CD8+ T cells from the spleens of HLA-A2 transgenic immunized mice were transferred to NSG (NOD/SCID/IL2Rγnull) mice with human ovarian or pancreatic tumors which were HER2-positive and HLA-A2-positive. NeuVax vaccination led to a specific, delayed-type hypersensitivity reaction and the induction of E75-specific CD8+ T cells that express PD-1. Growth rate for both ovarian and pancreatic tumors was significantly reduced in models of NSG mice that received the CD8+ T cells from NeuVax-immunized mice, compared to those receiving the cells from control mice.

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