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Comparing sensitivity and efficiency of N-ChIP-seq and X-ChIP-seq kits
May 2017
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Chromatrap
 
Chromatrap has published a new article that describes a detailed genome-wide comparison of native and crosslinked chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) using the company’s patented solid-state spin column technology.
 
This article compares the enrichment of the histone H3K4me3 modification signal across the whole genome, from chromatin prepared by both methods (native vs. cross link). The histone mark H3K4me3 was chosen for this study to highlight the sensitivity and efficiency of the Chromatrap spin column technology for both native and cross-linked ChIP-seq, as it is associated with “open” transcription start sites and gene activation and is present in euchromatin throughout the genome.
 
Chromatrap

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