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Good efficacy for Sarconeos in DMD
October 2017
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PARIS—This year’s World Muscle Society international congress saw Biophytis, a biotechnology company with a focus on developing treatments for age-related diseases, present an abstract titled “Sarconeos demonstrates sharp functional improvement and anti-fibrotic properties in an animal model of Duchenne muscular dystrophy.” Sarconeos is a first-in-class drug candidate developed to treat sarcopenia, an age-related degeneration of skeletal muscle that results in mobility loss. Its mode of action is based on the activation of the MAS receptor, a key facet of the renin-angiotensin system. Duchenne muscular dystrophy (DMD) is a new orphan indication for the drug. In a study, mouse models of DMD treated daily with Sarconeos for eight weeks saw statistically significant improvements in running distances (2.4-fold) compared to untreated mice, as well as a 15-percent improvement in maximal muscle force and a decrease in fibrosis, among other results.

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