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New reference standard from Horizon Discovery
March 2018
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CAMBRIDGE, U.K.—Horizon Discovery recently launched its cell line-derived epidermal growth factor receptor (EGFR) Multiplex cell-free DNA (cfDNA) Reference Standard, which enables laboratories and assay developers to optimize, validate and monitor the performance of PCR-based tests, next-generation sequencing and other assays designed to detect EGFR mutations in cfDNA. The reference standard covers 10 of the most clinically relevant mutations that predict responsiveness to EGFR tyrosine kinase inhibitors, including T790M, L858R, C797S and E746-A750del. It is cell line-derived and supplied in a DNA fragment range of 160 base pairs, and comes in a set of four vials with allelic frequencies from 5 percent down to 0.1 percent, along with a matched EGFR wild type.

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