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A new angle for protein identification
May 2018
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LA JOLLA, Calif.—Researchers out of the Sanford Burnham Prebys Medical Discovery Institute recently published a study detailing their development of a high-throughput, genome-scale imaging-based approach to assessing protein stability. As noted in the Cell Reports study, the team has used this approach to identify a number of previously unknown human proteins that are degraded by the HIV-1 accessory protein Vpu to support the infection process. The platform, Global Arrayed Protein Stability Analysis (GAPSA), identifies circuits that cause destruction of proteins in cells. The team identified proteins targeted by Vpu, which enables HIV to replicate
 
“Identifying Vpu target proteins creates an opportunity to find new drugs that block the interaction, potentially preserving host antiviral proteins and limiting HIV infection. Importantly, the system can be equally applied to other infectious diseases that evade the immune system, such as Ebola, influenza, Zika and others,” said Dr. Lars Pache, co-author of the paper.

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