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An antifungal acquisition
December 2019
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HALIFAX, Nova Scotia—Appili Therapeutics Inc. expanded its pipeline last month with the acquisition of T-2307 (now known as ATI-2307) under an agreement with FUJIFILM Toyama Chemical Co. Ltd. Appili gains exclusive worldwide rights (ex-Japan) to develop and commercialize ATI-2305, and in return will make future regulatory and commercial milestone payments to FUJIFILM Toyama Chemical, as well as a royalty on any net sales. The compound is a novel, broad-spectrum antifungal agent that is not currently susceptible to existing resistance mechanisms. ATI-2307 has shown broad-spectrum activity in vitro and in vivo against fungi such as Cryptococcus and multi-drug-resistant Candida. Appili plans to focus initially on advancing the compound as a treatment for cryptococcal meningitis. So far, ATI-2307 has been evaluated in three Phase 1 clinical studies showing it to be well tolerated in humans at anticipated dose levels.

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