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Enhanced GPCR screening
May 2008
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Cisbio

Cisbio announces the launch of its HTRF Terbium platform for GPCR screening, with the introduction of IP-One Tb and cAMP Tb. These assays mark the first products in Cisbio's second-generation HTRF technology pipeline to incorporate the Lumi4-Tb cryptate for enhanced screening performance. Lumi4-Tb, a Terbium cryptate developed by Lumiphore Inc. and licensed exclusively to Cisbio, is the newest member of Cisbio's family of cryptates on which HTRF chemistry is based. HTRF is Cisbio's highly sensitive, technology for the detection of molecular interactions in vitro and is widely used for primary and secondary screening phases of drug development. Lumi4-Tb's structure, a lanthanide tightly embedded in a surrounding macrocycle, remains very much in line with that of previous HTRF cryptates and shows superior stability compared to other Terbium complexes. It therefore allows for enhanced assay performance in terms of sensitivity, assay window, and robustness, without compromising the features and benefits that HTRF brings to assays: a "mix and measure" non-radioactive format, miniaturizable to uHTS formats, showing excellent robustness and a low compound interference rate.

Cisbio   
888-963-4567
www.htrf.com


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