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Tools to study genomic instability and genotoxic stress
October 2010
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Trevigen Inc.  
 
Trevigen Inc. has announced the availability of 19 DNA repair gene-knockdown cell lines, encompassing the Base Excision Repair pathway. These are target specific LN428 glioblastoma shRNA lentivirus transduced cells that are rigorously qualified and mycoplasma-free. Knockdown levels range from 75 percent to 98 percent as determined by RT-PCR. Lentiviruses are maintained by puromycin selection. DNA repair proteins maintain the stability of the genome. When repair protein function is impaired through mutations, the genome may become unstable—a hallmark of solid tumors. The availability of this panel of knockdown cell lines will permit scientists to study the molecular etiology of tumor genomic instability and to exploit it in oncology research.
 
Trevigen Inc.
(800) 873-8447
www.trevigen.com

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