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Fully automated measurement of therapeutic targetsí cellular activity
July 2011
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Roche

The recently developed xCELLigence RTCA HT Instrument from Roche Applied Science allows researchers to perform fully automated impedance screens for GPCRs and other targets in the 384-well high-throughput format. The xCELLigence System uses gold electrodes at the bottom surface of microplate wells as sensors to which an alternating current is applied. Cells that are grown as adherent monolayers on top of such electrodes influence the alternating current at the electrodes by changing the electrical impedance. The degree of this change is primarily determined by the number of cells, strength of the cell-cell interactions, interactions of the cells with the microelectrodes and by the overall morphology of the cells.  

Roche
+49 8856 604830
www.roche.com



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