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High Throughput Screening NEWS
2019-07-12
 
Code: E071926
2019-06-27
 
Code: E06271901
BMG Labtech
 
VEGF was fluorescently labeled at a single site. This ligand was used with HEK293 expressing VEGF-receptor 2 (VEGFR2) fused to NanoLuc®. Interaction between ligand and receptor leads to BRET between luciferase and fluorophore. Both signals were acquired simultaneously with the PHERAstar®. This way, pKi of a VEGF-inhibitor and time-course of inhibition were measured.
 
Receptor tyrosine kinases (RTK) such as VEGF are transmembrane receptors that translate stimulation by growth factors to cell death or cell growth. Aberrant RTK-signaling is implicated in cancer, making it a therapeutic target.
 
2019-05-13
 
Code: E051904
2019-03-26
 
Code: E03271901
2019-03-12
 
Code: E031907
2018-11-13
 
Code: E111829
BMG Labtech
 
YEATS domains are epigenetic regulators and readers of histone post-translational modifications. They bind to lysine when the ε-carbon is acylated. The YEATS-containing ENL is a major driver of several types of acute leukaemia and a rational drug target.
 
An AlphaScreen-based peptide binding assay was developed that reports on the interaction of modified histone 3 with the YEATS domains. Inhibitor screening was performed on a PHERAstar® and uncovered a potent small molecule inhibitor interfering with the YEATS domains of ENL and AF9.
 
2018-10-11
 
Code: E101806
2018-10-11
 
Code: E101821
2018-09-12
 
Code: E091829
2018-06-12
 
Code: E061801
2018-06-12
 
Code: E061835
2018-02-14
 
Code: E021821
2017-10-10
 
Code: E10111704
2017-09-14
 
Code: E091729
2017-09-12
 
Code: E091702
2017-04-14
 
Code: E041728
2017-04-14
 
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2017-03-12
 
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2016-11-10
 
Code: E111610
2016-09-13
 
Code: E091629
2016-03-10
 
Code: E031607
2016-02-16
 
Code: E021624
2016-02-16
 
Code: E021627
2015-12-09
 
Code: E121522
2015-12-07
 
Code: E121532
2015-11-13
 
2015-09-09
 
Code: E091530
2015-04-09
 
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2015-02-23
 
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2015-02-10
 
Code: E021528
2014-10-13
 
Code: E101409
2014-09-10
 
Code: E091406
2014-08-12
 
Code: E081422
2014-07-08
 
Code: E071428
2014-07-08
 
Code: E071421
2013-12-08
 
2013-11-11
 
Code: E111328
2013-10-08
 
Code: E101303
2013-06-03
 
Code: E061309
2013-04-05
 
2013-03-11
 
Code: E031321
2013-03-11
 
Code: E031307
2013-02-06
 
Code: E021309
2013-01-11
 
Code: E011315
2013-01-10
 
2012-12-11
 
Code: E121215
2012-07-05
 
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2012-06-06
 
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2012-05-09
 
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2012-03-13
 
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2012-01-12
 
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2012-01-12
 
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2011-09-07
 
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2011-08-09
 
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2011-04-07
 
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2011-02-08
 
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2011-01-04
 
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2011-01-04
 
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2010-12-09
 
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2010-11-10
 
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2010-09-08
 
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2010-08-09
 
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2010-05-05
 
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2010-04-01
 
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2010-03-08
 
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2010-01-27
 
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2010-01-05
 
2009-12-04
 
Code: E120918
2009-11-04
 
Code: E110915
2009-11-03
 
2009-11-03
 
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2009-10-26
 
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2009-06-01
 
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2009-05-05
 
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2009-04-06
 
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2009-04-03
 
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2009-03-09
 
2009-03-09
 
2009-03-06
 
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2009-01-14
 
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2008-12-10
 
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2008-12-10
 
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2008-10-21
 
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2008-10-21
 
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2008-10-21
 
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2008-09-19
 
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2008-08-25
 
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2008-04-21
 
2008-03-27
 
Code: e030816
2008-01-08
 
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2007-12-11
 
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2007-11-14
 
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2007-11-14
 
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2007-06-18
 
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2007-06-12
 
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2007-05-07
 
2007-03-26
 
2007-02-23
 
2007-01-09
 
2007-01-08
 
2006-09-25
 
2006-08-08
 
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2006-04-22
 
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2005-05-23
 
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2005-03-24
 
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2005-03-24
 
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2005-03-23
 
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2005-03-23
 
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0000-00-00
 
Code: E081024
0000-00-00
 
Code: E071120


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