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Pocket change: Thermo Fisher buys Cohesive for $25 million
WALTHAM, Mass.—Thermo Fisher Scientific Inc. announced the acquisition of Massachusetts-based Cohesive Technologies Inc., a manufacturer of advanced TLX turbulent flow sample extraction and liquid chromatography products. Cohesive has annual revenues of approximately $15 million.
The Cohesive product line enhances the company's Thermo Scientific portfolio by adding in-line sample preparation capabilities that couple with mass spectrometry technology to create end-to-end workflow solutions for drug and other organic molecule analyses. These new capabilities will significantly improve sample throughput and increase detection limits during LC/MS/MS analysis for customers in the pharmaceutical, clinical, environmental and food science industries.
"Cohesive's sample preparation technologies will strengthen our ability to offer customers the advanced tools they need to accelerate research and discovery and to provide them with higher-quality analytical information," said Marijn E. Dekkers, president and CEO of Thermo Fisher Scientific. "We look forward to integrating Cohesive into Thermo Fisher Scientific, and to making their sample preparation capabilities available to customers worldwide through our global sales channels."
Jeff Zonderman, vice president, sales & marketing at Cohesive, notes that the new relationship to Thermo Fisher Scientific will make the advantages of Cohesive's patented technology available on a much wider scale.
"Cohesive's system allows chromatographers to perform turbulent flow chromatography to eliminate solid phase extraction (SPE), liquid/liquid extraction (LLE) or protein precipitation (PPT)," Zonderman explains.
The TLX system injects samples directly onto a narrow diameter TurboFlow column that is packed with large particles. Using the principles of turbulence, diffusion, and chemistry, the small sample molecules are separated from the sample matrix in the column.
When the mobile phase flows through the column, linear velocities are created which are 100 times greater than what is typically seen in HPLC columns, the company claims. The large interstitial spaces between the column particles and the high linear mobile phase velocity create turbulence within the TurboFlow column. Since small molecular weight molecules diffuse faster than large molecular weight molecules, the small sample compounds diffuse into the particle pores. The turbulent flow of the mobile phase quickly flushes the large sample compounds through the column to waste before they have an opportunity to diffuse into the particle pores. A mobile phase change then elutes the small molecules that were bound by the TurboFlow column to the mass spectrometer or to a second analytical column for further separation. No forecast was provided of the increased sales for the system expected due to the Thermo Fisher acquisition.