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IOTest reagents for natural killer (NK) cell studies
December 2007
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Beckman Coulter Inc. introduces two new IOTest reagents: Anti-NTB-A-PE and CD226 (DNAM-1)-PE.  Both are monoclonal antibodies (mAbs) to cell surface receptors for NK (natural killer) cell studies, which provide important information in disease research.  These new flow cytometry reagents are compatible with Beckman Coulter's FC 500 series and Cell Lab Quanta SC systems as well as other instrument platforms. The IOTest Anti-NTB-A-PE reacts with a member of a newly discovered family of NK receptors called SLAM (signaling lymphocyte activation molecule), which are important functional receptors in lymphocytes and other leukocytes.  In certain cases of NTB-A expression, downstream mechanisms are thought to be involved in induction of T cell costimulation and in regulation of B cell tolerance. IOTest CD226 (DNAM-1)-PE recognizes a putative cell-corruption surveillance receptor in NK and cytotoxic T lymphocyte cells.  It may also play a role in transendothelial cell migration.  These two new antibodies complete Beckman Coulter's NK-targeted mAb family.  The preformulated, standardized IOTest Anti-NTB-A-PE and CD226 (DNAM-1)-PE antibodies are provided in 50-test vials and are labeled for research use only.
Beckman Coulter Inc
800-742-2345

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