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New method expands flow cytometry immune monitoring capabilities
February 2010
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Beckman Coulter Inc.
Beckman Coulter Inc. is now offering Streptamer technology, providing a novel method for the isolation and characterization of functional antigen-specific T-cells by fluorescence-activated or magnet-assisted cell sorting. Streptamer technology, manufactured by IBA GmbH, includes Ag-specific multimers available in a number of human alleles and mouse models and attached to either magnetic beads or fluorescently labeled Strep-Tactin. The addition of the Streptamer technology to Beckman Coulter's iTAg MHC Tetramer and iTopia Immune Monitoring product lines provides researchers with a comprehensive range of methods for sorting and characterizing cells. Combined with current Tetramer and iTopia reagents, Streptamer technology allows researchers to expand their use of tetramers to include in vivo experimentation. The reversible, antigen-specific staining of T-cells enabled by Streptamers leaves the isolated T-cells phenotypically and functionally indistinguishable from untreated cells. The technology has the potential to advance basic T-cell research as an essential prerequisite for novel immunological medicines.

Beckman Coulter Inc.
(800) 742-2345
www.beckmancoulter.com

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