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Nanoscale Peptide Separation System, GE Healthcare
April 2006
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GE Healthcare recently launched a nanoscale 1D-LC peptide separation system that combines excellent reproducibility with accurate performance. The Ettan nanoLC is a fully bio-inert, robust, nanoscale peptide separation system that, according to GE Healthcare, delivers highly reproducible performance and is ideal for 1D-LC proteomics applications upstream from electrospray ionization MS or MALDI MS/MS applications. The nanoLC extends the range of applications of GE Healthcare's family of Ettan chromatography systems.  The nanoLC is designed for those with limited funding requiring a dedicated 1D-LC system who don't want to compromise on the high sensitivity enabled by the LC platform. The Ettan nanoLC performs high-pressure gradient formation with high reproducibility and online, real-time gradient monitoring, while maintaining a continuous flow to the ion source or MALDI spotter throughout a run. The instrument's low dead volumes ensure minimum peak broadening and consistent peak concentrations for maximum sensitivity and resolution. The bio-inert system offers advantages for peptide separation of labile phosphopeptides upstream from electrospray ionization MS. Integrated system components include a flow splitter that ensures  gradient elution at flow rates as low as 200 nL/min, UV and conductivity monitors, the P-905 pump, a pressure sensor, and biocompatible flow path and pump heads. The Peltier-cooled Autosampler A-905 allows injection of as little as 100 nL of sample from vials or microtiter plates.

GE Healthcare
800.526.3593

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