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Expansion of assay options for the study of metabolism and drug-drug interactions
INDIGO has completed development of the next generation of pregnane X receptor (PXR) technology. Previously available in kits and services for only human and rat PXR, INDIGO has expanded its PXR products and services portfolio to include dog, monkey and mouse assays.
PXR regulates genes critically involved in drug metabolism and clearance.
The introduction of these new kits and services allows for even greater end-stage success predictability due to high levels of interspecies correlation. PXR’s importance spans across the pharmaceutical, nutriceutical and agri-business industries. INDIGO’s PXR assay kits include everything required to properly screen for PXR activation.
The assay kits are all-inclusive systems, including optimized media for use during cell culture and in preparing test compound treatments, a PXR reference agonist, luciferase detection reagents and an assay plate.