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System combines top-down and bottom-up proteomics to improve biomarker discovery
November 2009
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Bio-Rad Laboratories Inc. and Bruker Corp.

Bio-Rad Laboratories Inc. and Bruker Corp. have jointly launched the Lucid Proteomics System, the first system to combine top-down and bottom-up proteomics approaches for biomarker discovery. With both techniques on one platform, the Lucid Proteomics System accelerates biomarker research programs by improving the chances of discovering biomarkers that have clinical relevance. The system combines Bio-Rad's ProteinChip surface-enhanced laser desorption/ionization (SELDI)-based array technology with Bruker's ultrafleXtreme matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) mass spectrometer. The top-down solution includes high-throughput protein profiling and identification of biomarker candidates, either by direct on-chip TOF/TOF analysis suitable for small peptides, or by enrichment, purification and digestion followed by TOF/TOF analysis for larger proteins. For the bottom-up approach, Bruker's ultrafleXtreme MALDI-TOF/TOF offers unmatched performance with high sensitivity, resolution and mass accuracy. 
 
Bio-Rad Laboratories Inc.
(510) 724-7000
Bruker Corp.

(978) 663-3660
www.lucidproteomics.com 
 

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