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Standardization of direct detection of DNA damage in cells
November 2009
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Amsbio
 
Amsbio has announced a novel complete assay system for direct detection of DNA damage in cells that includes CometSlides, reagents, control cells and an electrophoresis unit. The comet assay is the only direct method for the detection of DNA damage in cells. It is used in cancer research, in genotoxicity studies on environmental mutagens and for screening compounds for cancer therapeutics. Based on single-cell gel electrophoresis in a controlled pH environment, the assay allows the integrity of stained nuclear DNA to be examined and measured. The complete assay system includes CometSlides, reagents, control cells and an electrophoresis unit which retains test cells in a uniquely configured electrophoretic field permitting consistent DNA migration patterns, which are critical for standardization of the assay. Each lot of the CometAssay control cells, reagents and CometSlides are tested and qualified for use in the CometAssay System. In combination, the components of the system permit reproducibility and reduce variability between individual users and different laboratories.  

Amsbio

+44-1235-828200
www.amsbio.com

 

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