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FEATURED NEW PRODUCT: Caliper LabChip EZ Reader
February 2011
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Mobility Shift Assay improves fragment-based screening candidate selection
Caliper Life Sciences
 
Fragment-based lead discovery is establishing itself as valuable approach for the discovery of novel small-molecule leads. It relies on establishing a better understanding of the binding mechanism of a ligand for its binding partner by probing for "hot spots" on the protein target with small molecule fragments. The LabChip EZ Reader microfluidic mobility shift assay is an alternative to traditional biochemical assays for fragment-based screening. In addition, it has the capability to provide structural insights that compliment techniques like NMR. The MMSA provides a direct readout of the product conversion and substrate remaining, a direct measure of enzyme inhibition (or activation). There is no need for coupling reagents (antibodies) or secondary enzymes; this dramatically reduces the likelihood of losing valuable time and data due to assay artifacts.
 
Caliper Life Sciences
(508) 435-9500
 

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