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New answers, efficacy data in MS
August 2019
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OTTAWA, Canada—Preclinical data of Orion Biotechnology Canada Ltd.’s OB-002 (5P12-RANTES) from a murine model of multiple sclerosis (MS) was recently published in Science Translation Medicine. In a new preclinical model of multiple sclerosis that features early-life viral infection in the brain, it was found that sites of cleared virus turn into lesion sites associated with MS-like pathology when autoimmune encephalomyelitis (EAE) is induced. EAE lesions contain inflammatory leukocyte because sites of cleared virus are long-term production sites for CCL5, a ligand of CCR5. Systemic administration of OB-002 was found to fully block the development of the lesions and the associated pathology.
 
“It is very exciting to have identified a possible pathway linking virus infection early in life to MS pathology, and intriguing that it should be dependent on the activation of a single chemokine receptor,” said Prof. Doron Merkler, who led the work.

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